T Cell Transfer-Induced Colitis Model

Transfer of T cells from wild-type donors into syngeneic immunodeficient mice lacking T and B cells reliably induces pancolitis and small intestinal inflammation. At Ace Therapeutics, we offer customized CD45RB^hiCD25^- T cell transfer-induced colitis models to help clients explore the immunological mechanisms underlying IBD and evaluate the efficacy of novel therapeutic candidates.

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Accelerate Your IBD Research with Our CD45RB^hiCD25^- T Cell Transfer-Induced Colitis Model

Understanding the immunological foundations of IBD is key to developing transformative therapies. Ace Therapeutics' CD45RB^hiCD25^- T cell transfer-induced colitis model offers a robust aplatform for exploring T cell-driven intestinal inflammation and evaluating the efficacy of novel therapeutic candidates.

What You'll Gain from the Case Study

Download the case study to explore:

Detailed experimental design and cell transfer protocol
Quantitative data showing immune activation, cytokine elevation, and colonic pathology
High-resolution histology images highlighting hallmark IBD lesions
Key findings demonstrating how this model supports mechanistic exploration and drug efficacy validation

Comprehensive Readouts and Analytical Capabilities

We provide a full suite of quantitative and histopathological endpoints, including:

Body weight and disease activity index (DAI)
Spleen and mesenteric lymph node (mLN) weights
Colon length, weight, and histological architecture
Cytokine profiling in colon tissue
H&E staining with detailed immune and epithelial lesion analysis

Download the case study to see how our CD45RB^hiCD25^- T cell transfer-induced colitis model can advance your understanding of IBD pathogenesis and accelerate your preclinical drug development.

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T Cell Transfer-Induced Colitis Model

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